MOTS‐c is a peptide of 16 amino acids expressed by a mitochondrial gene. Research provides evidence that mitochondria play a key role in signaling and in energy production.
MOTS-c is known to regulate metabolic functions throughout the body, including turning glucose into usable energy. The first studies on MOTS-c were conducted on obese mice. They showed that the peptide helped boost glucose metabolism even when the mice were fed a high fat diet. These preliminary studies show evidence for improved control over blood sugar levels for those with type 2 diabetes and obesity.
Research also shows that skeletal muscle is the major target tissue of MOTS‐c. The skeletal muscle enhances insulin sensitivity and increases glucose uptake in myocytes (muscle cells) by activating the AMPK pathway and at the same time without increasing insulin. Research concluded it is fair to call MOTS‐c an exercise‐mimetic, meaning it imitates exercise on the body. Exercise also increases muscle glucose uptake without stimulating insulin.
Research has shown the following potential benefits of MOTS-c:
- Promotes fatty acid metabolism in the liver.
- Promotes metabolic flexibility and homeostasis.
- Helps regulate mitochondrial energy.
- Protects against age and diet dependent insulin resistance and obesity.
- Helps with weight loss.
- Promotes resistance to metabolic stress.
- Improves exercise capacity.
- Helps prevent osteoporosis.
- Improves glucose regulation.
Purity, Formulation & Physical Appearance
iPharmix MOTS-c has a peptide purity level that exceeds 99.0% as determined by HPLC. This peptide was synthesized with no additives and is supplied as a white lyophilized (freeze-dried) powder.
Solubility & Storage
It is recommended to reconstitute the lyophilized MOTS-c in bacteriostatic water, which can then be further diluted in other aqueous solutions. Lyophilized MOTS-c although stable at room temperature for 90 days, should be stored between 2-8°C. Upon reconstitution, MOTS-c should be stored between 2-8°C out of direct light for up to 14 days. For future use store below -18°C. Prevent repeated freeze-thaw cycles.
THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product is not a drug and has not been approved by the FDA to prevent or cure any medical condition or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.
Peptide Sequence: MRWQEMGYIFYPRKLR
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.6 g/mol
PubChem CID: 146675088
CAS Number: 1627580-64-6